Frequency of Prediabetes in Patients Presenting for Routine Checkup in Outpatient Department

Sajid  Ali; Uzma  Batool

doi:10.54112/bcsrj.v6i6.1727

Authors

Sajid Ali Department of Medicine, Pakistan Atomic Energy Commission General Hospital, Islamabad, Pakistan
Uzma Batool Department of Medicine, Pakistan Atomic Energy Commission General Hospital, Islamabad, Pakistan

DOI:

https://doi.org/10.54112/bcsrj.v6i6.1727

Keywords:

Body Mass Index (BMI), HbA1c, Obesity, Outpatient Checkups, Prediabetes, Sedentary Lifestyle, Type 2 Diabetes Risk

Abstract

Prediabetes is an intermediate metabolic state of elevated blood glucose levels that fall below the threshold for diabetes diagnosis. Often asymptomatic, it serves as an early warning sign for the future development of type 2 diabetes. Objective: To determine the frequency of prediabetes and evaluate associated demographic and lifestyle risk factors among patients attending routine outpatient checkups. Methods: This cross-sectional study was conducted at the Department of Medicine, PAEC General Hospital, Islamabad, from December 2024 to May 2025. A total of 201 patients aged 20–70 years, attending for routine checkups, were included through non-probability consecutive sampling. HbA1c was measured to assess glycemic status. Prediabetes was defined as HbA1c levels between 5.7% and 6.4%. Results: Prediabetes was detected in 26 out of 201 patients (12.9%). A statistically significant association was found between prediabetes and both BMI ≥30 (p = 0.03) and sedentary lifestyle (p = 0.048). No significant associations were observed with gender, age, smoking status, place of residence, or income. Logistic regression analysis confirmed obesity and physical inactivity as independent predictors of prediabetes. Conclusion: It is concluded that the frequency of undiagnosed prediabetes is substantial in patients presenting for routine OPD checkups. Obesity and sedentary lifestyle were key risk factors. Routine HbA1c screening should be integrated into outpatient settings to enable early detection and preventive care.

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References

Moradpour F, Rezaei S, Piroozi B, Moradi G, Moradi Y, Piri N, et al. Prevalence of prediabetes, diabetes, diabetes awareness, treatment, and its socioeconomic inequality in west of Iran. Sci Reports.2022;12:17892. https://doi.org/10.1038/s41598-022-22779-9

Lailler G, Piffaretti C, Fuentes S, Nabe HD, Oleko A, Cosson E, et al. Prevalence of prediabetes and undiagnosed type 2 diabetes in France: results from the national survey ESTEBAN, 2014–2016. Diabetes Res Clin Pract. 2020;165:108252. https://doi.org/10.1016/j.diabres.2020.108252

Rutkowski M, Wojciechowska A, Śmigielski W, Drygas W, Piwońska A, Pająk A, et al Prevalence of diabetes and impaired fasting glucose in Poland in 2005-2014: results of the WOBASZ surveys. Diabet Med. 2020;37(9):1528-35. https://doi.org/10.1111/dme.14333

Drobek N, Sowa P, Jankowski P. Undiagnosed diabetes and prediabetes in patients with chronic coronary syndromes an alarming public health issue. J Clin Med. 2021;10:1981. https://doi.org/10.3390/jcm10091981

Carris NW, Magness RR, Labovitz AJ. Prevention of diabetes mellitus in patients with prediabetes. Am J Cardiol. 2019;123:507-12. https://doi.org/10.1016/j.amjcard.2018.10.032

Kitchlew R, Chachar AZK, Haider M, Saleem AR, Mirza MS, Latif S, et al. Pre-Diabetes; prevalence of pre-diabetes in our local population. Professional Med J. 2017;24(12):1860-66. https://doi.org/10.17957/TPMJ/17.4310

Ampeire IP, Kawugezi PC, Mulogo EM. Prevalence of prediabetes and associated factors among community members in rural Isingiro district. BMC Public Health.2023;23:958.

Al-Zahrani JM, Aldiab A, Aldossari KK, Al-Ghamdi S, Batais MA, Javad S, et al. Prevalence of prediabetes, diabetes and its predictors among females in alkharj, saudi arabia: a cross-sectional study. Annals of Global Health. 2019;85(1):1–13. https://doi.org/10.5334/aogh.2467

Hasan SU, Siddiqui MR. Nationwide prevalence of type 2 diabetes mellitus and pre-diabetes in Pakistan: A systematic review and meta-analysis. Diabetes Research and Clinical Practice. 2024 Aug 22:111815. https://doi.org/10.1016/j.diabres.2024.111815

Shehzad, ., Kalimullah, ., Hanan, A. ., Yasir, ., & Fawadullah, . (2025). Frequency of Prediabetes in Patients With High BMI Presenting to a Tertiary Care Hospital. Biological and Clinical Sciences Research Journal, 6(3), 93–96. https://doi.org/10.54112/bcsrj.v6i3.1627

Duan D, Kengne AP, Echouffo-Tcheugui JB. Screening for Diabetes and Prediabetes. Endocrinol Metab Clin North Am. 2021 Sep;50(3):369-385. http://doi.org/10.1016/j.ecl.2021.05.002 .

Nolan CJ, Prentki M. Insulin resistance and insulin hypersecretion in the metabolic syndrome and type 2 diabetes: Time for a conceptual framework shift. Diabetes and Vascular Disease Research. 2019;16(2):118-27. http://doi.org/10.1177/1479164119827611

Speight J, Holmes‐Truscott E, Hendrieckx C, Skovlund S, Cooke D. Assessing the impact of diabetes on quality of life: what have the past 25 years taught us? Diabetic Medicine. 2020;37(3):483-92. http://doi.org/10.1111/dme.14196

Patel MR, Tolentino DA, Smith A, Heisler M. Economic burden, financial stress, and cost-related coping among people with uncontrolled diabetes in the US. Preventive Medicine Reports. 2023;34:102246. http://doi.org/10.1016/j.pmedr.2023.102246

de Boer IH, Khunti K, Sadusky T, Tuttle KR, Neumiller JJ, Rhee CM, et al. Diabetes management in chronic kidney disease: a consensus report by the American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO). Diabetes care. 2022;45(12):3075-90. http://doi.org/10.2337/dci22-0027

Cleven L, Krell-Roesch J, Nigg CR, Woll A. The association between physical activity with incident obesity, coronary heart disease, diabetes and hypertension in adults: a systematic review of longitudinal studies published after 2012. BMC public health. 2020;20:1-15 http://doi.org/10.1186/s12889-020-08715-4